Nodding rattlesnake-root is an erect forb, 1-2.5m tall, with a corymb-like inflorescence, generally branched, flowers mature from the bottom upward, heads nod, with 15-38 ochre-colored, bisexual flowers, and a tan or sordid pappus (modified calyx). Its stem is smooth below the somewhat glandular, slightly hairy inflorescence. Its fruits are elongate, smooth, mostly reddish-brown achenes. Leaves are alternate, smooth or rough above, generally with short, coarse, stiff hairs at least on the midrib and main veins, most are petiolate, elliptic to deltoid, cordate, coarsely toothed to occasionally shallowly lobed or entire, only gradually reduced upward. Blades are up to 25cm long by 20mm wide.